On March 31, 2015, Khalid Alamoud Ortho 19, DScD 19 was awarded the Goldman School of Dental Medicine Dean’s Award for Student Research at the Graduate Research Symposium, an annual event highlighting research being conducted by Boston University graduate students. Participants in the symposium come from both the Medical Campus and the Charles River Campus. Five Boston University Henry M. Goldman School of Dental Medicine (GSDM) students participated in the event which took place in the George Sherman Union. Participants presented posters during one of two poster sessions, which included presentations from over 160 participants.
Alamoud received the award for his poster titled, “Targeting the N-glycosylation regulating gene DPAGT1 for Oral Cancer.” He is conducting his doctoral research in the lab of Associate Dean for Research and Professor in the Department Molecular & Cell Biology Dr. Maria Kukuruzinska.
Dr. Kukuruzinska’s lab is investigating the molecular events that underlie oral cancer development. Oral cancer, which presents primarily as oral squamous cell carcinoma (OSCC), is an aggressive disease with limited available treatment options. The Lab’s research has shown that protein N-glycosylation is regulated by the DPAGT1 gene which functions at the first rate limiting step in the N-glycosylation pathway. Alamoud’s poster discussed how this gene promotes oral cancer cell migration in vitro, and tongue tumor formation and metastasis in vivo, identifying DPAGT1 as a likely and novel candidate target for OSCC therapies. Additional collaborators on this work included Research Technician Mr. Trevor Packer, Research Associate Dr. Jie Hui Li, and Research Assistant Professor in the Department of Molecular & Cell Biology Dr. Manish Bais.
Alamoud was honored to receive the award and is grateful for the support he has received at GSDM. “It is with deepest appreciation that I express my thanks to Dean Hutter for his continued support, Dr. Kukuruzinska for her guidance and expertise, as well as the Graduate Research Symposium,” he said. “It is an honor to be acknowledged by a symposium which highlights research from so many different disciplines across the university.”
The other GSDM student poster presentations at the symposium included:
“Oral Squamous Cancer Cell-Bone Interactions and Resistance to Alendronate (Fosamax) Drug Therapy in 3D-Live Bone-Microenvironment” by Melody Hwang PERIO 17 (MSD); post-doctoral student Zhongyan Wang; Professor and Chair of the Department of Periodontology Dr. Serge Dibart; and Research Associate Professor in the Department of Periodontology Dr. Erdjan Salih.
“Sex-linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice” by Eileen Daley ORAL BIO 17 (PhD); Loai Alsofi ORAL BIO 08, ENDO 11 (MSD), ENDO 12; post-doctoral student Elise F. Morgan; Zachary D. Mason ENG 10; Professor in the Department of Obstetrics and Gynecology at the University of Texas Southwestern Medical Center Dr. Jesus F. Acevedo; Professor in the Department of Obstetrics and Gynecology at the University of Texas Southwestern Medical Center Dr. R. Ann Word; Louis C. Gerstenfeld GRS 82; and Professor and Director of Graduate Programs in the Department of Molecular & Cell Biology Dr. Philip Trackman.
“Densitometric Analysis of Protease Enzyme Activities in Whole Saliva” by Daniah AlHarkan ORAL BIO 17 (MSD), PERIO 17; Laboratory Supervisor Ms. Nerline Grand-Pierre, Grace Hannawi DMD 17, Post-doctoral Associate in the Department of Molecular & Cell Biology Na Tian ORAL BIO 14 (PhD), Yi Zhong ORAL BIO 15 (MSD), Research Assistant Professor in the Department of Molecular & Cell Biology Dr. Guoxian Wei, and Associate Professor in the Department of Molecular & Cell Biology Dr. Eva Helmerhorst.
“Not-yet-cultivated Bacteria of in vivo Formed Early Dental Biofilm” by Debora Heller ORAL BIO 16 (PhD), Associate Professor in the Department of Molecular & Cell Biology Dr. Eva Helmerhorst; Adam Gower ENG 12; Associate Professor of Dentistry and Biochemistry at Western University in Canada Dr. Walter Siqueira; Chair of the Department of Microbiology at the Forsyth Research Center Dr. Bruce Paster; and Professor in the Departments of Periodontology and Molecular & Cell Biology and Henry M. Goldman Distinguished Scientist Dr. Frank Oppenheim.
Dean Jeffrey W. Hutter said, “The Graduate Research Symposium is an excellent opportunity to highlight the exceptional research being conducted at GSDM.” He continued, “I would also like to congratulate Khalid on his excellent poster. We are very proud of the great work he is doing.”